Is Esketamine Covered By Insurance?

Is Esketamine covered by insurance?

Esketamine, a variant of the anesthetic drug ketamine, is a medication that has been approved by the FDA for treatment-resistant depression. It works differently from traditional antidepressants, which predominantly target serotonin. Instead, esketamine has a direct effect on brain cells, promoting growth and connectivity in areas related to mood regulation.

Since its FDA approval, insurance coverage for esketamine treatment has become more accessible, although it may still vary depending on your specific insurance plan and individual circumstances. The medication used for Esketamine treatment, called Spravato, has been covered by most major insurance providers for in-network treatments.

While traditional ketamine treatments can vary in cost and may not be covered by insurance, esketamine’s approval and more standardized administration through a nasal spray format has made it a more accessible option for individuals seeking treatment-resistant depression relief. Insurance coverage for ketamine therapy depends on various factors such as your diagnosis, medical history, and the form of treatment pursued.

It is essential that you consult with your insurance provider and healthcare professional to determine the extent of coverage for esketamine treatment. Some insurance providers may require precertification for Spravato, which usually involves submitting relevant documentation to establish the medical necessity of the prescribed treatment.

If esketamine treatment is deemed appropriate for your condition, implementing it as a part of your mental health regimen could potentially provide significant benefits in managing treatment-resistant depression. Always discuss your options with your healthcare provider to ensure that you pursue the most effective and appropriate course of treatment for your unique situation.

Esketamine’s FDA Approval

Esketamine, a ketamine derivative, received FDA approval in 2019 under the brand name Spravato. It is specifically designed for patients with treatment-resistant depression (TRD). As a nasal spray, it offers rapid relief with its quick onset of action, alleviating depression symptoms within hours after administration.

Esketamine is administered as a nasal spray, with a single squirt in each nostril followed by a two-hour monitoring period. Its rapid delivery system is designed to provide effective, fast-acting relief in comparison to traditional oral antidepressants, which can take weeks or even months to show significant improvement.

FDA Approval Challenges:

  • Despite its promising potential, esketamine’s FDA approval process was met with some challenges. It is essential to note that although it is a more potent version of ketamine, it is not a silver bullet for depression.
  • The approval process for esketamine was scrutinized due to inconsistent clinical trial results. However, it was deemed beneficial for individuals who did not find relief from traditional treatments.
  • Esketamine’s FDA approval has opened the door for insurance coverage, but it is not a guarantee. Coverage for Spravato can vary based on your insurance provider and plan.

Regarding insurance coverage, esketamine is FDA-approved, which increases the likelihood of insurance companies covering the treatment. However, it’s important to keep in mind that coverage for Spravato is not universal and can vary based on your insurance.

In summary, esketamine’s FDA approval was a significant step in treating treatment-resistant depression, offering rapid relief through its unique delivery system. However, it is essential to be aware of the challenges in obtaining insurance coverage for the treatment, as it can vary depending on your provider and plan.

The Role of Spravato

Spravato, or esketamine, is a nasal spray medication that has been approved by the FDA for use in treating treatment-resistant depression. It is typically prescribed to patients who have not responded well to other antidepressants. The effectiveness of Spravato makes it an essential option for those struggling with severe depression.

As a nasal spray, Spravato is easy to administer. You will generally visit a certified treatment center where a healthcare professional will administer the medication to you under supervision. This ensures both proper dosing and monitoring for any potential side effects.

MedicationSpravato (esketamine) nasal spray
Condition TreatedTreatment-resistant depression
AdministrationNasal spray
Supervised TreatmentYes, administered at certified treatment centers

When it comes to insurance coverage for Spravato, it depends on your specific health insurance plan. Some plans, such as those with Blue Cross Blue Shield, may cover the medication depending on your diagnosis and plan provisions. Coverage criteria vary by state and insurance provider, so it is essential to review your plan or reach out to your insurance provider for details on coverage.

The convenience and effectiveness of Spravato make it an essential option for those who have not found relief through other antidepressant medications. By addressing treatment-resistant depression, Spravato plays a critical role in improving the overall mental health and wellbeing of patients who may otherwise have limited options. Remember to consult with your healthcare provider and insurance company to determine if Spravato is the right choice for you and if it is covered by your plan.

Depression and Esketamine

Esketamine is an FDA-approved medication used to treat treatment-resistant depression. Unlike common antidepressants that can take weeks to show effects, esketamine provides fast relief, with a noticeable impact on brain cells and symptoms experienced within hours.

Compared to traditional antidepressants, esketamine is particularly effective for those struggling with anxiety and persistent suicidal thoughts. Research has shown that it can significantly reduce depression symptoms, with its effects lasting for weeks following the treatment.

When it comes to insurance coverage, esketamine may be partially covered due to its FDA-approved status for treatment-resistant depression. It is essential to check with your insurance plan and provider to understand the costs associated with esketamine treatment. It is important to note that esketamine treatment does not include psychotherapy, which can be a crucial aspect of addressing mental health issues.

In addition to its benefits for treatment-resistant depression, esketamine has also shown promise in addressing other mental health conditions, such as anxiety, bipolar disorder, and obsessive-compulsive disorder. It is crucial to speak with your healthcare provider to determine if esketamine is an appropriate option for your specific situation and needs.

To summarize, esketamine offers a faster-acting solution for individuals struggling with treatment-resistant depression, anxiety, and suicidal thoughts. It may be partially covered by insurance. However, it is important to bear in mind that esketamine treatment is not a substitute for counseling and other forms of psychotherapy that address the root causes of mental health issues.

Is Spravato Covered by Insurance?

Spravato, also known as esketamine, is an FDA-approved treatment for treatment-resistant depression (TRD) in adults. Its effectiveness has made it a popular option for those seeking relief from their symptoms. As a result, you may wonder whether insurance covers this promising treatment.

Coverage for Spravato depends on your specific insurance plan. Several insurance companies, such as Blue Cross Blue Shield, Gilsbar, Humana Military, Triwest, Multiplan, PHCS, Zelis, PPO Plus, United Healthcare, United Behavioral Health, and Cigna Behavioral Health are known to provide coverage for this treatment.

However, it’s crucial to remember that the extent of coverage can vary between plans, even within the same insurance provider. Always consult your insurance company to confirm the exact details of your coverage and policy.

When considering Spravato treatment, you should also be aware that you may be required to go through a precertification process. For instance, Aetna requires precertification of esketamine nasal spray for all participating providers and members in applicable plan designs. You will need to follow your insurance company’s precertification procedures to access Spravato coverage.

In conclusion, coverage for Spravato varies depending on your insurance plan and provider. Make sure to thoroughly research your insurance policy and follow the necessary procedures to seek coverage for this treatment. Stay confident and knowledgeable in your pursuit of relief from treatment-resistant depression.

How Much is Spravato Without Insurance

Spravato, also known as esketamine, is a relatively new medication and can have quite a substantial cost when purchased without insurance. The price may vary depending on factors such as the dosage and location. Let’s take a look at the approximate cost of Spravato without insurance coverage to help you better understand the financial aspect involved.

The cost for Spravato can range from $784.12 for 2 sprays of 28 mg (84 mg dose) to around $1,171.42 for 3 sprays. These prices represent a single dose, and multiple doses may be needed for a complete treatment, which can significantly increase the total cost. It’s important to note that these prices are only estimates, and the actual cost may be different depending on the pharmacy or location.

If affordability is an issue, there are ways to save on Spravato’s cost, such as using a manufacturer coupon to reduce the price. Some programs can also help you receive your prescription at no charge if you’re eligible.

Furthermore, Janssen, the manufacturer of Spravato, offers financial support for those who need help paying for their medication or understanding their insurance coverage. Assistance programs like these are beneficial in making the treatment more accessible to a larger number of people.

Keep in mind that Spravato has specific administration requirements; you cannot take it at home. It must be administered under the supervision of a healthcare professional, and you should be monitored for at least two hours after each dose.

In conclusion, the cost of Spravato without insurance can be quite high, but assistance programs, manufacturer coupons, and financial support from the manufacturer can make the treatment more affordable. It is always best to consult with your healthcare provider and explore your options for obtaining this medication in the most cost-effective way.

Esketamine Cost with Insurance

Esketamine is a prescription medication used to treat depression and other mental health conditions. The cost of esketamine treatment can vary depending on your insurance coverage. Some insurance providers may partially or fully cover the cost of esketamine therapy, while others may not.

In some cases, insurance providers may cover certain aspects of esketamine treatment, such as designating the treatment as “an infusion of a generic drug”. Therefore, it is essential to discuss your insurance coverage options with your insurance representative before starting treatment.

The SPRAVATO® nasal spray, which contains esketamine, can be covered by some insurance plans. To determine if your insurance covers SPRAVATO®, consider asking your insurance provider the following questions:

  • Is SPRAVATO® medication covered under my medical or pharmacy benefit?
  • Are my SPRAVATO® visits covered under my medical plan or do I have a behavioral health benefit?
  • What is my co-pay or cost share for SPRAVATO® treatment?

Regarding ketamine therapy costs, even if your insurance company doesn’t fully cover ketamine therapy, they might take care of some of the costs. Often insurers will cover the office visit, consultation fee, and psychiatric care.

In conclusion, esketamine treatment costs can vary based on your particular insurance coverage. Be sure to discuss these options and potential costs with your healthcare provider and insurance representative before making any decisions on whether to proceed with treatment.

Spravato Cost with Insurance

Esketamine, marketed under the brand name Spravato, is a nasal spray used for treating treatment-resistant depression. The cost of Spravato can be a concern for many patients, especially those without insurance coverage. However, many insurance providers cover Spravato to some extent.

When considering the cost of Spravato with insurance, it’s crucial to understand your specific insurance plan’s coverage. Coverage typically varies depending on the plan and the provider. It is a good idea to contact your insurance provider to inquire about their coverage of Spravato and any copays or deductibles that may apply.

To help with affordability, Spravato’s manufacturer offers a patient support program called SPRAVATO withMe. This program provides personalized treatment support and affordability assistance for eligible patients. To enroll in the program, consult with your doctor and ask about SPRAVATO withMe.

For those who are still struggling with the cost, other cost-saving options are available, such as the manufacturer coupon that allows eligible patients to pay as little as $10 per treatment. Additionally, the Johnson & Johnson Patient Assistance Foundation, Inc. offers a patient assistance program for eligible patients to receive their prescription at no charge.

Though esketamine’s cost with insurance depends on your specific plan and provider, various options, such as the SPRAVATO withMe program and manufacturer coupons, can help ease the financial burden. Always consult your medical professional and insurance provider for personalized information and guidance on your situation.

Does Blue Cross Blue Shield Cover Spravato?

Blue Cross Blue Shield (BCBS) insurance coverage for Spravato (Esketamine) depends on your specific health plan and diagnosis status. While it is included in several policies, it is important to consult with your insurance provider to confirm the precise terms of coverage.

Spravato is an N-methyl-D-aspartate (NMDA) receptor antagonist and is prescribed in conjunction with an oral antidepressant. It is indicated for the treatment of treatment-resistant depression (TRD) in adults and for dealing with depressive symptoms in patients with Major Depressive Disorder (MDD) who have acute suicidal ideation or behavior.

BCBS Esketamine nasal spray coverage requires certain criteria to be met before insuring this drug. These criteria may vary by state and insurance provider, making it crucial to check the specific requirements for your location and plan. To give you an idea of the factors insurance providers may consider, here’s a brief overview:

  • Diagnosis: Confirming the diagnosis of TRD or MDD with acute suicidal ideation is essential.
  • Treatment history: Previous attempts to treat depression using conventional methods must be documented to establish the need for Spravato.
  • Treatment plan: The use of Spravato must be combined with an oral antidepressant in a comprehensive treatment program.

As with any medication, coverage and requirements can change over time, so it is always best to consult with your insurance provider for the most up-to-date information about Spravato coverage under your Blue Cross Blue Shield plan.

In summary, Spravato coverage under a BCBS plan depends on various factors, including your specific health plan and diagnosis status. It is essential to consult your insurance provider and healthcare professional for comprehensive information and guidance regarding your eligibility for Spravato coverage.

Is Spravato Nasal Covered by Insurance?

Spravato™ (esketamine) is a prescription nasal spray that, when used in combination with oral antidepressants, is designed to treat adults with treatment-resistant depression (TRD) and depressive symptoms in adults with major depressive disorder (MDD) 1. Though the U.S. Food & Drug Administration (FDA) approved this drug on March 5, the question of whether insurance covers the cost of this treatment remains relevant for many patients.

Spravato™ cannot be administered at home and must be used under the supervision of a healthcare professional, followed by at least a two-hour monitoring period 2. As a result, the costs associated with this treatment go beyond the price of the drug itself, which can range from $784 for a supply of 2 sprays 3.

Since its approval for use by the FDA for treatment-resistant depression in 2019, people have been paying an average of $4,700 to $6,800 for their initial month of the nasal spray 4. Due to the high cost of this drug, coverage through insurance services, including Medicare, is crucial for many patients seeking treatment.

In some cases, Spravato™ is indeed covered by insurance. For example, Neuromend Center, a clinical provider of the medication, states that they now offer insurance coverage for Spravato™ 1. On the other hand, Medicare Part B coverage is typically provided for this drug due to its high cost 4. However, individual insurance coverage in regard to Spravato™ can still vary depending on a patient’s specific insurance plan, coverage levels, and other factors.

As a result, it’s essential for patients to consult with their insurance providers and healthcare professionals to determine their coverage eligibility for Spravato™. By doing so, they can obtain accurate information about their plan’s benefits and limitations, allowing them to make informed decisions about their depression treatment options.


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Is Spravato Covered by Medicaid?

Spravato (esketamine) is a prescription nasal spray approved by the U.S. Food and Drug Administration to treat adults with treatment-resistant depression (TRD) or major depressive disorder (MDD) with suicidal thoughts or actions 1. Medicaid coverage for Spravato may vary depending on specific policies and criteria established by each state’s Medicaid program.

Some states may have established coverage criteria for Spravato. For instance, the New York State Medicaid Fee-for-service program has approved certain criteria for esketamine (Spravato) nasal spray under both the Pharmacy and Medical Benefit 2. It is crucial to check with your state’s Medicaid program since policies may vary from state to state.

Since Medicaid is a state-specific program, you should contact your state’s Medicaid office or consult with your healthcare provider to determine if Spravato is covered by your Medicaid plan. Also, you may want to explore additional resources such as patient assistance programs offered by the manufacturer of Spravato if you find that your Medicaid coverage does not include this medication.

Remember to always consult with your healthcare provider to determine if Spravato is appropriate for you and if your insurance will cover it.


  1. Esketamine and Ketamine Therapy – Yale New Haven Hospital
  2. Practitioner Administered Drug Update: New York State Medicaid Fee-for-Service Policy

Is Spravato Covered by Medicare

Spravato, a brand name for esketamine, is a nasal spray used for the treatment of depression, specifically treatment-resistant depression (TRD) in adults. Its administration occurs within a medical facility under the supervision of a healthcare provider. The question of whether Medicare covers Spravato is essential for beneficiaries who may require this treatment.

Yes, Medicare covers Spravato if your doctor recommends it. Medicare Part B becomes a crucial element in Spravato coverage due to the medication’s high cost. Medicare Advantage (Part C) policies may also cover Spravato treatments, as these plans include services offered by both Parts A and B. However, coverage and out-of-pocket costs may vary depending on your specific Medicare Advantage plan.

It is essential to verify with your plan provider whether Spravato is covered under your Medicare plan and the financial responsibility you will have. The Centers for Medicare & Medicaid Services provides billing and coding guidelines for esketamine, indicating its coverage for the treatment of TRD in adults.

Remember to consult with your healthcare provider and Medicare plan to ensure that you understand the coverage and any out-of-pocket costs associated with Spravato treatments.

Does CIGNA cover Esketamine?

CIGNA, a leading insurance provider, offers coverage for various medications and treatments. When it comes to esketamine, a nasal spray medication used to treat depression, the coverage may vary. Esketamine, also known as Spravato, is a prescription drug designed for patients who have not responded well to other treatments.

CIGNA’s coverage for esketamine is determined by their medical necessity review process. According to their coverage policy, ketamine (Ketalar), a similar drug, is not covered for psychological conditions. This implies that coverage for esketamine may be subject to specific criteria and approval processes.

To find out if your CIGNA plan covers esketamine, it’s important to consult the Prescription Drug List and Coverage provided by your specific health plan. This resource will give you information on the covered medications, their costs, and any limitations or exclusions applicable to your plan.

In summary, while CIGNA may cover esketamine for some individuals, the coverage is likely subject to specific criteria and approval processes. To determine if your plan covers it, consult your CIGNA Prescription Drug List and Coverage information and discuss with your healthcare provider. Remember that each individual’s coverage may vary, so it’s essential to understand the specific details of your insurance plan.

G Codes and S Codes

When it comes to esketamine (Spravato), insurance coverage may vary, and it’s essential to understand the different billing codes that healthcare providers use when dealing with reimbursement. Two primary codes are used for esketamine: G codes and S codes.

G codes are utilized for Medicare and some commercial payers, such as G2082 for 56mg and G2083 for 84mg. These codes include both the cost of the drug and the administration service. S codes, on the other hand, are product-specific billing codes designed to facilitate commercial payer claims processing for Spravato, such as S0013. These codes describe only the drug and do not include professional services.

It’s crucial for healthcare providers to consult with each patient’s insurance plan to determine the appropriate codes to use, as coverage can differ significantly. While esketamine itself has no unique, designated code for its observation and monitoring during administration, providers must continue to report G codes on Medicare claims for proper reimbursement.

Code TypeEsketamine DosageIncludesUsage
G codesG2082: 56mgDrug + ServicesMedicare claims
G2083: 84mg
S codesS0013Drug onlyCommercial payers

In conclusion, understanding the distinction between G codes and S codes is essential for healthcare providers administering esketamine. These codes impact insurance coverage and reimbursement, so it’s crucial to consult with each patient’s insurance plan and use the appropriate codes for accurate claims processing.

We analyze the ketamine therapy cost, low cost ketamine treatments, the cost of 4-hour ketamine infusion, cost of at-home ketamine therapy,

We respond to some questions from the comments section: Is ketamine infusion covered by insurance?, Why is ketamine treatment so expensive?, Is ketamine treatment covered by Medicaid?, Does Blue Cross Blue Shield Cover Ketamine Treatment?, Is Ketamine Infusion Covered by Medicare?, How to Get Ketamine Infusions Covered by Insurance, Is Esketamine Covered By Insurance?,

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